Longer Half-Life Progestin-Only Contraceptive Pill Now Available
Oral contraceptive options recently expanded with a new progestin-only pill (POP) called drosperinone 4 mg. Drosperinone is to be taken once daily and has a cycle of 24 active pill days followed by 4 placebo pill days. What sets drosperinone apart from norethindrone, the only other POP currently on the market, is the advantage of drosperinone’s longer half-life (~30 hours). Drosperinone allows a 24 hour missed dose window during which patients are not at an increased risk for pregnancy. This is a more favorable half-life than combined oral contraceptives containing estrogen and is 20 hours longer than norethindrone. For patients with cardiovascular risk factors that preclude them from taking estrogen, drosperinone would be an effective and more forgiving progestin-only oral contraceptive option. For more information on progestin-only pills click here.
Published May 2021