The AAP published interim guidance on the use of leucovorin in pediatric patients with autism and an accompanying FAQ document for pediatric prescribing clinicians. The AAP does not recommend routine use of leucovorin (folinic acid) for children with autism due to limited evidence on its safety and effectiveness. The AAP expresses support for continued research into promising therapies, and provides recommendations for talking to families about leucovorin. Additional information is available below:
- Interim Guidance: Interim Guidance from the American Academy of Pediatrics: Use of Leucovorin in Autistic Pediatric Patients
- FAQs for Pediatric Prescribing Clinicians: Frequently Asked Questions (FAQs) for Pediatricians and other Prescribing Pediatric Clinicians: Leucovorin Use in Autism and Cerebral Folate Deficiency
- AAP News: https://publications.aap.org/aapnews/news/33649
- HealthyChildren.org: https://www.healthychildren.org/English/health-issues/conditions/Autism/Pages/Autism-Spectrum-Disorder.aspx